In vitro activity of polyphenol‐rich extract of sorghum relevant to treatment of Alzheimer’s disease

Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that accounts for most dementia cases. It has become serious international health and economic concern as there no effective treatment. Naturally derived products, particularly polyphenols (PP), have very popular developing therapeutic strategies AD. PP apply their neuroprotective actions through targeting various pathological hallmarks of the disease, such Aβ and/or aggregation, oxidative stress mitochondrial dysfunction. aggregation majorly implicated in pathogenesis Therefore, finding way to attenuate Aβ-induced toxicity could be potential approach disease-modifying treatments In current study, effect polyphenolic extract from different sorghum varieties was assessed against Aβ42-induced cytotoxicity. Method A cell viability assay (MTS) utilized assess protective extracts on cytotoxicity human neuroblastoma BE (2)-M17 cells. Following that, thioflavin T (Th-T) performed anti-Aβ extracts. Result The significantly increased viability. Of six tested extracts, QL33(2000 µg/ml) B923296(1000 demonstrated strongest weakest decreasing death (p < 0.01), respectively. addition, were at inhibiting aggregation. Conclusion Sorghum promising therefore can considered naturally agent AD However, further studies are required confirm anti-AD effects these